Conclusionsīoth somatic and drug-induced causes of death were common during OAT. Increasing somatic comorbidity, measured by the Charlson comorbidity index, reduced the odds of dying of a drug-induced cause of death compared with other causes of death. In general, CMRs increased with age, and they were higher in men and in patients taking methadone compared with buprenorphine. Somatic disease was the most common cause of death (45%), followed by drug-induced death (42%), and violent death (12%). The mean age at the time of death was 48.9 years (standard deviation 8.4), and 74% were men. A forensic or medical autopsy was performed in 63% of the cases. In the 2-year observation period, 200 (1.4%) of the OAT patients died. We included all patients in the Norwegian OAT programme who died not more than 5 days after the last intake of OAT medication, between 1 January 2014 and 31 December 2015. Data from the Norwegian Cause of Death Registry and the Norwegian Patient Registry were combined with data from medical records. This was a national, observational register study. The aims of this study were to describe the causes of death among OAT patients in Norway, to estimate all-cause and cause-specific crude mortality rates (CMRs) during OAT and to explore characteristics associated with drug-induced cause of death compared with other causes of death during OAT. Because of the varying mortality rates and causes of death in different subgroups and countries, research gaps still exist. Norway has one of the oldest OAT populations in Europe. Patients in OAT are ageing due to effective OAT as well as demographic changes, which has implications for morbidity and mortality. Mortality rates and causes of death among individuals in opioid agonist treatment (OAT) vary according to several factors such as geographical region, age, gender, subpopulations, drug culture and OAT status.
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